CBD for High Blood Pressure
A very important human study investigated the impact of CBD for high blood pressure while testing is still carried out on animals under most circumstances.
CBD is a naturally occurring plant-derived enzyme with highly beneficial health effects, one of which contributes to a significant decrease in blood pressure. Cannabis and hemp’s complicated legal situation continues to obstruct global CBD science, and human studies remain very uncommon.
This pioneering, double-blind 2017 placebo-controlled study first investigated whether CBD lowers human blood pressure, and was inspired by pre-clinical trials indicating that CBD has a range of cardiovascular benefits.
The study included nine healthy male volunteers who received either a 600 mg CBD or a placebo dose.
The findings showed that those who took the 600 mg dose of CBD had the following:
- Reduced systemic blood pressure remaining (– 6 mmHg; P < 0.05)
- Enhanced cardiac output
- A lower volume of stroke (– 8 ml; P<0.05)
- Heart production controlled
The data also suggested that the CBD dose was obtained from the respondents:
- Reduces before and after tension blood pressure (– 5 mmHg; P < 0.05)
- Heart rate increased (+10 bpm; P < 0.01)
- Low volume of stroke (– 13 ml; P < 0.01)
Finally, volunteers who received 600 mg CBD had in response to cold stress:
- Blood pressure reduction (– 6 mmHg; P < 0.01)
- Heart rate (+7 bpm; P<05) Heart rate improved
- Higher overall resistance to peripherals
Investigators found that a single CBD administration lowers blood pressure while lowering blood pressure due to stressful conditions, as well as decreases blood pressure.
How Much CBD Should You Take to Lower Your Blood Pressure?
The participants in the study received a considerably large single dose of CBD (600mg), which could be considered as a very expensive treatment method for most people.
High blood pressure is an extremely dangerous problem for your health, so if you intend to use CBD in your diet the dosage should be higher than less harmful conditions such as anxiety or insomnia, for example.
Why can't CBD be taken?
People respond differently to CBD, primarily because of their age, health, and genetic differences. These variations make it a personal study that typically needs some fine-tuning to find the optimal dose of CBD.
It is best to start with the intermediate dose (about 60 mg CBD per day) for this particular condition and see how you respond. Two 30 mg CBD capsules per day can also be used to reach this dosage. It is recommended to have a “CBD log” which helps you to monitor the exact effects of various CBD doses and your daily intake.
Why do some people need more time to benefit from CBD?
Some people instantly perceive the effects of CBD, while others don’t seem to notice the difference. There is still a question about whether this is exactly what is happening and no clear answers yet.
The endocannabinoid system deficiency is one of the key theories (and my favorite personal one. By “encouraging” cells of the endocannabinoid system, the way CBD (and all other cannabinoids) induce its positive effects.
Imagine CBD molecules as keys, that cause a particular cell reaction when entering the “bolt” (receptor). An endocannabinoid system is a large number of cells in the entire body and thus CBD can accommodate so many specific circumstances and conditions.
Some people have a “malfunctioning” endocannabinoid system due to age variations, specific biology, general health, and many other complex factors.
This means that the cells of an endocannabinoid system malfunctioning will not respond the same way as the cells of an endocannabinoid system that works properly.
The theory also suggests that the endocannabinoid system can be “restored” by sustained exposure to cannabinoids such as CBD in its cells. Usually, this process takes a few weeks.
The whole task needs commitment and determination, but because CBD is entirely normal and widely accepted in the majority, it is not much a risk to try.
Potential Side Effects of CBD
Just like the percentage of people who don’t experience relief from CBD right away, some individuals tend to have adverse effects from CBD, while most users don’t have any noticeable issues.
This is also most likely due to age, overall health, personal chemistry, and genetic differences.
Luckily, most of the potential side effects of CBD are not too serious and can be considered only a nuisance. They include:
- Fatigue (especially at large doses)
- Irritability (also at large doses)
- Decreased appetite
This whole medical area is sadly not yet well known. Only by try using CBD can you decide which group of users you belong to.
It’s important to understand that the potential side effects are not hazardous in any way.
CBD is metabolized by an enzyme known as CYP3A4
A high proportion of prescription drugs, including certain blood pressure medicines, are metabolized in the CYP3A4 enzyme.
That essentially means that if your body simultaneously metabolizes both CBD and the other compound, both substances must be metabolized in a single, non-good way, by the CYP3A4 enzyme.
The metabolization of other drugs in your system will decrease with CBD and the other drug will stay at high levels too long.
This mechanism can also be reversed, as the CYP3A4 enzyme ‘focuses’ more on the other drug that lies inside the body in the CBD molecules.
The interactions with other CBD drugs are very critical, so take them extremely seriously and carry out your research by investigating extensively the drug you are taking.
Some medicines do not have a grapefruit warning, therefore, search for any mention of the CYP3A4 enzyme in the inserted material.
You should consult your doctor too, but CBD and its drug interactions are still not (in most cases) well understood.
High blood pressure is a severe disease, and if you intend to bring the involvement of CBD to your current treatment program, thorough testing is necessary.