The Truth About THCv Effects On Alzheimer's Disease
Tetrahydrocannabivarin or THCV effects are the most commonly detected psychoactive cannabinoid in Sativa’s cannabis varieties. A more inspired, alert, and intense feeling of euphoria is established. That’s why accessibility is generally suggested particularly during the daytime or at any time.
Thus, the removal of toxic clumps of amyloid-beta protein in the brain which has to continue the development of Alzheimer’s disease was established as an active marijuana compound named tetrahydrocannabinol (THC).
The Surprising Ways THCv Can Improve Your Life
THCV effects reduce stress and research demonstrates that anxiety and panic attacks can be reduced or even prevented. That is why Post-Traumatic Stress Disorder (PTSD) has a significant role to play. It is also neuroprotective, rendering it suitable for the management of diseases like Alzheimer’s, Parkinson’s disease, and MS. In comparison to THC, THCV is intended to reduce hunger, and cachexia or anorexia nervosa is not prescribed for patients.
This study confirms the findings of previous studies that have demonstrated that cannabinoids, including THC, have positive effects on patients with neurodegenerative disorders.
Studies Show The Effectivity Of THCV On Alzheimer'S Patients
“While other researchers have given proof that marijuana may function as neuroprotective against Alzheid symptoms,” one team, David Schubert from the Salk Institute for Biological Research, California, said, “we believe that our work was the first to show that marijuana’s influence both inflammation and beta-amyloid in the nerve cell.
THCv ‘s impact on human neurons in a study, imitated by Alzheimer”s influence, was examined by Schubert and his colleagues.
If you do not learn about this unique drug, it’s also recognized as a successful cure for the effects of anything including Aids and chemotherapy to chronic Depression, post-traumatic stress disorders, and stroke that accounts not just for the bulk of neurological-but strong marijuana, due to its nature’s pain-relieving properties.
What Are The THCV Benefits?
THCv appears to be such an amazing therapeutic agent, and researchers are involved in breeding a genetically engineered yeast that can manufacture it far more effectively than conventional variants might have been.
The drug acts by traveling from the lungs to the bloodstream link to the two receptor groups, 1 and 2, which are located in cells in the body, the cannabinoid receptor (CB).
Throughout the brain, these receptors are often localized throughout neurons connected with gratification, learning, thinking, balance, and sense of time, which typically bind to groups of lipid molecules referred to as endocannabinoids, which the body generates for cell-into-cell signaling in the brain.
Yet Cannabinoids will still connect you to the same degree, so when they do, you tend to screw with the capacity of your brain to interact with yourself. We can be right and incorrect, and whether you miss anything important or can’t swing a bat at once, you still feel great and want to consume all the snacks.
How Does THCv Work With The Brain?
Over the years, work has shown that linking THCv with these receptors may have a particular impact on the old brains, as it appears to help the body eliminate the harmful accumulations of amyloid-beta (or ‘plaques’).
Nobody is completely sure what causes Alzheimer’s disease, although two forms of lesions, amyloid plaques, and neurofibrillary tangles, are believed to arise from the build-up.
Amyloid plaques are situated between neurons as dense clusters of beta-amyloid molecules – a sticky protein type that clump with ease – and neurofibrillary tangles are caused by defective, insoluble neuron proteins that clump to a thick mass.
While it is not clear why these lesions appear in the brain, studies have linked brain tissue inflammation to plaque and neurofibrillary encounters. Therefore, if we can discover anything that promotes activation of the brain while at the same time helping the body to remove these lesions, we could be on the way to the first possible Alzheimer’s care.
THCV is used in a variety of medical conditions
The most common ones are:
- THCV’s principal claim to fame is its ability to reduce anxiety and depression. A study published in the Journal of Psychopharmacology found that THCV could reduce anxiety-like behaviors when given to rats on the elevated plus-maze test. Another study published in Pharmacology Biochemistry and Behavior showed that THCV was able to significantly reduce symptoms of depression in mice.
- Besides being an anti-anxiety agent, THCV has also been shown to have anti-inflammatory properties through its inhibition of COX-2 enzyme production, as well as its ability to increase levels of anandamide (AEA), an endogenous cannabinoid neurotransmitter known for its pain-relieving effects. A study published in Neuropharmacology found that THCV could reduce inflammation in rats by inhibiting COX-2 enzyme production while increasing levels of 2-arachidonoylglycerol (2-AG), another endocannabinoid involved in inflammation modulation.
- Pain relief. THCV can be used to treat chronic pain, such as back pain, arthritis, and other pains that don’t respond to common treatments. THCV has been shown to reduce the symptoms of multiple sclerosis (MS), spinal cord injury, and other types of nerve pain.
- Weight loss. THCV may help reduce the risk of obesity by increasing energy expenditure, reducing food intake, and suppressing appetite. It also helps increase HDL (“good”) cholesterol levels in the blood.
- Neuroprotection. THCV can protect against brain damage caused by stroke or trauma by inhibiting the production of inflammatory molecules called cytokines. It also reduces cell death caused by oxidative stress and prevents further damage from glutamate toxicity — which occurs when too much glutamate builds up in your brain cells and kills them off because of an overactive NMDA receptor activity.
What Are The THCV Side Effects?
THCV is an appetite stimulant, so it can cause nausea in some patients. This side effect is not common, however, and most people tolerate THCV very well. Less common side effects include:
- Stomach pain
Findings and Results!
Scientists at the Scripps Research Institute found in 2006 that THCv inhibits amyloid plaques to form, suppressing the brain enzyme that creates them, and Schubert and his colleagues have now demonstrated it can also remove harmful inflammatory reactions from the nerve cells, thereby ensuring their longevity.
“Inflammation in the brain is the key component of Alzheimer’s disease disruption, but the reaction has long been thought to come from immune like brain cells, not the nerve cells themselves,” said one of the team leaders, Antonio Currais.
“When the molecular basis for inflammatory reaction to amyloid-beta may have been established, it was apparent that THC-like compounds would help prevent nerve cells from dying.”
The Results Are In: What The Lab Results Actually Say
It is interesting news, but so far only neurons have been tested in the laboratory, and Schubert and his colleagues must pursue it phase in a clinical study to look into the link between THCv effects and reduced inflammation and plaque formation.
A drug candidate called J147 has reportedly already found that it has the same effects as THCv so that they can test THC’s impacts without the government interfering.
Furthermore, these findings have been published in Aging and Mechanisms of Disease. Though it’s worth adding that more recent legal changes since the time of this research around marijuana use in the USA may be making further research in this area a lot easier.
THC is the psychoactive component of marijuana that makes you high. THCV (tetrahydrocannabivarin) is a non-psychoactive cannabinoid found in cannabis. It’s a cousin of THC with many of the same medicinal properties and therapeutic benefits.
THCV is found in relatively high concentrations in sativa strains of cannabis but also exists in some indica strains. It’s also been isolated from hemp seeds and marketed as a supplement or extracted for topical creams.
Like THC, THCV has been shown to reduce nausea and vomiting, decrease intraocular pressure (IOP) associated with glaucoma, and improve appetite. It also may help people with Crohn’s disease by suppressing inflammation.
THCV is not as euphoric as THC, but it produces an uplifting and creative effect. It may also reduce some of the negative effects of THC, such as anxiety, paranoia and memory loss.
THCV has been shown to reduce seizures in animal studies. A study published in the journal Epilepsy Research found that THCV can protect brain cells from injury caused by seizures or brain damage.
A study published in the Journal of Neuroimmune Pharmacology found that THCV may improve cognitive function in those with multiple sclerosis (MS). The researchers suggest THCV could be useful for treating inflammation-related diseases such as MS because it blocks CB1 receptors while enhancing CB2 receptors. This means that it has anti-inflammatory properties without causing psychoactive effects, such as euphoria or paranoia.
The strength of THCV depends on the specific strain and its concentration level. Some strains have higher levels of THCV than others. The following are general estimates based on average percentages:
- 5 percent THCV dosage: This is like a high dose of CBD (about 1 mg/kg). It produces euphoria, relaxation, and anxiety reduction without causing sleepiness or drowsiness.
- 10 percent THCV: This is like an average dose of CBD (about 3 mg/kg). It produces euphoria, relaxation, and anxiety reduction without causing sleepiness or drowsiness.
- 15 percent THCV: This is like a potent dose of CBD (about 5 mg/kg). It produces euphoria, relaxation, and anxiety reduction without causing sleepiness or drowsiness.
THCV is not a stimulant. It is actually a mildly psychoactive cannabinoid that can help treat conditions like anxiety, stress, and depression. It works by activating the CB1 receptor, which is the same receptor activated by THC. This means that if you take THCV on its own taking no other cannabinoids, it will not get you high.
THCV does not get you high because it does not activate CB1 receptors in your brain — this causes you to feel “high” from marijuana. However, if you combine THCV with other cannabinoids (like CBD), then you can experience an uplifting effect from the combination of THCV and CBD’s anxiolytic effects.
While THCV has some therapeutic benefits, there isn’t much research available on this cannabinoid just yet. There have been some animal studies done on the effects of THCV, but no human trials have been done yet.